1389. Pharmacokinetic/Pharmacodynamic (PK/PD) Evaluation of a Novel Aminomethylcycline Antibiotic, KBP-7072, in the Neutropenic Murine Pneumonia Model Against S. aureus (SA) and S. pneumoniae (SPN)

BACKGROUND: KBP-7072 is a novel aminomethylcycline antibiotic with broad-spectrum activity that includes organisms with drug-resistance to β-lactams and tetracyclines. We examined the PK/PD relationship between KBP-7072 drug exposures and treatment effect using a neutropenic murine pneumonia model a...

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Vydáno v:Open Forum Infect Dis
Hlavní autoři: Lepak, Alexander J, Zhao, Miao, Liu, Qingmei, Wang, Ping, Wang, Yanli, Bader, Justin C, Ambrose, Paul G, Andes, David R
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6252832/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy210.1220
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