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166. TGF-β Restricts T-cell IFNg Production in Pulmonary Tuberculous Granulomas

BACKGROUND: IFNg production by CD4 T cells has been thought to be critical for immunity against Mycobacterium tuberculosis (Mtb); however, recent studies show that IFNg-producing CD4 T cells are more effective at preventing dissemination than controlling Mtb in the lung. Because optimal control of M...

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Detalhes bibliográficos
Publicado no:Open Forum Infect Dis
Main Authors: Gern, Benjamin, Adams, Kristin, Plumlee, Courtney, Gerner, Michael, Urdahl, Kevin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6252666/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy209.036
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