1387. Phase I Study to Evaluate the Safety and Pharmacokinetics (PK) of Single and Multiple Ascending Doses (SAD/MAD) of Intravenous (IV) Minocycline in Healthy Adult Subjects

BACKGROUND: Carbapenem-resistant Acinetobacter baumannii infections are defined by the WHO as a critical threat. IV minocycline is approved in the United States for treatment of Acinetobacter infections at doses up to 200 mg BID. This study investigated safety and PK of single and multiple doses of...

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Detalhes bibliográficos
Publicado no:Open Forum Infect Dis
Main Authors: Cornely, Oliver A, Arenz, Dorothee, Barraud, Olivier, Bayliss, Mark, Dimitriou, Vassiliki, Hamacher, Stefanie, Lovering, Andrew M, MacGowan, Alasdair, Cammarata, Sue K, Fusaro, Karen, Griffith, David C, Morgan, Elizabeth, Loutit, Jeffery S
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
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Abstracts
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6252552/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofy210.1218
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