Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays

XMAP215/Stu2/Alp14 proteins accelerate microtubule plus-end polymerization by recruiting tubulins via arrays of tumor overexpressed gene (TOG) domains, yet their mechanism remains unknown. Here, we describe the biochemical and structural basis for TOG arrays in recruiting and polymerizing tubulins....

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Nithianantham, Stanley, Cook, Brian D, Beans, Madeleine, Guo, Fei, Chang, Fred, Al-Bassam, Jawdat
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251626/
https://ncbi.nlm.nih.gov/pubmed/30422110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.38922
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