Abcc6 Knockout Rat Model Highlights the Role of Liver in PPi Homeostasis in Pseudoxanthoma Elasticum

Pseudoxanthoma elasticum (PXE), a heritable ectopic mineralization disorder, is caused by mutations in the ABCC6 gene primarily expressed in the liver and the kidneys. The fundamental question on pathogenesis of PXE, whether lack of ABCC6 expression in liver or kidney is the primary site of molecula...

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Bibliographic Details
Published in:J Invest Dermatol
Main Authors: Li, Qiaoli, Kingman, Joshua, van de Wetering, Koen, Tannouri, Sami, Sundberg, John P., Uitto, Jouni
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251403/
https://ncbi.nlm.nih.gov/pubmed/28111129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2016.11.042
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