GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions

BACKGROUND: Although diabetic retinopathy (DR) has long been considered as a microvascular disorder, mounting evidence suggests that diabetic retinal neurodegeneration, in particular synaptic loss and dysfunction of retinal ganglion cells (RGCs) may precede retinal microvascular changes. Key molecul...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Zhu, Huazhang, Zhang, Weizhen, Zhao, Yingying, Shu, Xingsheng, Wang, Wencong, Wang, Dandan, Yang, Yangfan, He, Zhijun, Wang, Xiaomei, Ying, Ying
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6251088/
https://ncbi.nlm.nih.gov/pubmed/30466464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0295-z
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