Locally anchoring enzymes to tissues via extracellular glycan recognition

Success of enzymes as drugs requires that they persist within target tissues over therapeutically effective time frames. Here we report a general strategy to anchor enzymes at injection sites via fusion to galectin-3 (G3), a carbohydrate-binding protein. Fusing G3 to luciferase extended bioluminesce...

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Pubblicato in:Nat Commun
Autori principali: Farhadi, Shaheen A., Bracho-Sanchez, Evelyn, Fettis, Margaret M., Seroski, Dillon T., Freeman, Sabrina L., Restuccia, Antonietta, Keselowsky, Benjamin G., Hudalla, Gregory A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6250738/
https://ncbi.nlm.nih.gov/pubmed/30467349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07129-6
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