Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H: quinone oxidoreductase 1 (NQO1)

The human NAD(P)H:quinone oxidoreductase 1 (NQO1; EC 1.6.99.2) is an essential enzyme in the antioxidant defence system. Furthermore, NQO1 protects tumour suppressors like p53, p33(ING1b) and p73 from proteasomal degradation. The activity of NQO1 is also exploited in chemotherapy for the activation...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:FEBS J
Auteurs principaux: Lienhart, Wolf-Dieter, Strandback, Emilia, Gudipati, Venugopal, Koch, Karin, Binter, Alexandra, Uhl, Michael K., Rantasa, David M., Bourgeois, Benjamin, Madl, Tobias, Zangger, Klaus, Gruber, Karl, Macheroux, Peter
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6250432/
https://ncbi.nlm.nih.gov/pubmed/28236663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14051
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires