Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H: quinone oxidoreductase 1 (NQO1)

The human NAD(P)H:quinone oxidoreductase 1 (NQO1; EC 1.6.99.2) is an essential enzyme in the antioxidant defence system. Furthermore, NQO1 protects tumour suppressors like p53, p33(ING1b) and p73 from proteasomal degradation. The activity of NQO1 is also exploited in chemotherapy for the activation...

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Detalhes bibliográficos
Publicado no:FEBS J
Main Authors: Lienhart, Wolf-Dieter, Strandback, Emilia, Gudipati, Venugopal, Koch, Karin, Binter, Alexandra, Uhl, Michael K., Rantasa, David M., Bourgeois, Benjamin, Madl, Tobias, Zangger, Klaus, Gruber, Karl, Macheroux, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6250432/
https://ncbi.nlm.nih.gov/pubmed/28236663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.14051
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