Metformin sensitizes hypoxia-induced gefitinib treatment resistance of HNSCC via cell cycle regulation and EMT reversal

OBJECTIVES: The objectives of this study were to explore the mechanisms of metformin sensitization to hypoxia-induced gefitinib treatment in resistant head and neck squamous cell carcinoma (HNSCC) and evaluate the effects of this combined treatment strategy. METHODS: The effects of gefitinib treatme...

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Detalhes bibliográficos
Publicado no:Cancer Manag Res
Main Authors: Yin, Xiteng, Wei, Zheng, Song, Chuanhui, Tang, Chuanchao, Xu, Wenguang, Wang, Yufeng, Xie, Junqi, Lin, Zitong, Han, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6250113/
https://ncbi.nlm.nih.gov/pubmed/30510448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/CMAR.S177473
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