FMRP Interacts with C/D Box snoRNA in the Nucleus and Regulates Ribosomal RNA Methylation

FMRP is an RNA-binding protein that is known to localize in the cytoplasm and in the nucleus. Here, we have identified an interaction of FMRP with a specific set of C/D box snoRNAs in the nucleus. C/D box snoRNAs guide 2’O methylations of ribosomal RNA (rRNA) on defined sites, and this modification...

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Publicado en:iScience
Autores principales: D'Souza, Michelle Ninochka, Gowda, Naveen Kumar Chandappa, Tiwari, Vishal, Babu, Rosana Ottakandathil, Anand, Praveen, Dastidar, Sudhriti Ghosh, Singh, Randhir, Selvaraja, Bhuvaneish, Pal, Rakhi, Ramesh, Arati, Chattarji, Sumantra, Chandran, Siddharthan, Gulyani, Akash, Palakodeti, Dasaradhi, Muddashetty, Ravi S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249352/
https://ncbi.nlm.nih.gov/pubmed/30469012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.11.007
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