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PERSPECTIVES ON THE OPTIMAL GENETICALLY-ENGINEERED PIG IN 2018 FOR INITIAL CLINICAL TRIALS OF KIDNEY OR HEART XENOTRANSPLANTATION

For a clinical trial today, what might realistically be the optimal pig among those currently available? Deletion of expression of the 3 pig carbohydrate antigens against which humans have natural (preformed) antibodies (triple-knockout [TKO] pigs) should form the basis of any clinical trial. Howeve...

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Vydáno v:Transplantation
Hlavní autoři: Cooper, David K.C., Ezzelarab, Mohamed, Iwase, Hayato, Hara, Hidetaka
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249080/
https://ncbi.nlm.nih.gov/pubmed/30247446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000002443
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