Molecular dynamics simulation of the follicle-stimulating hormone receptor. Understanding the conformational dynamics of receptor variants at positions N680 and D408 from in silico analysis

Follicle-stimulating hormone receptor (FSHR) is a G-protein coupled receptor (GPCR) and a prototype of the glycoprotein hormone receptors subfamily of GPCRs. Structural data of the FSHR ectodomain in complex with follicle-stimulating hormone suggests a “pull and lift” activation mechanism that trigg...

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Publicado en:PLoS One
Autores principales: Jardón-Valadez, Eduardo, Castillo-Guajardo, Derik, Martínez-Luis, Iván, Gutiérrez-Sagal, Rubén, Zariñán, Teresa, Ulloa-Aguirre, Alfredo
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6248991/
https://ncbi.nlm.nih.gov/pubmed/30462715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0207526
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