Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial

IMPORTANCE: There are few effective treatments for heart failure with preserved ejection fraction (HFpEF). Short-term administration of inorganic nitrite or nitrate preparations has been shown to enhance nitric oxide signaling, which may improve aerobic capacity in HFpEF. OBJECTIVE: To determine the...

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Detalhes bibliográficos
Publicado no:JAMA
Main Authors: Borlaug, Barry A., Anstrom, Kevin J., Lewis, Gregory D., Shah, Sanjiv J., Levine, James A., Koepp, Gabe A., Givertz, Michael M., Felker, G. Michael, LeWinter, Martin M., Mann, Douglas L., Margulies, Kenneth B., Smith, Andrew L., Tang, W. H. Wilson, Whellan, David J., Chen, Horng H., Davila-Roman, Victor G., McNulty, Steven, Desvigne-Nickens, Patrice, Hernandez, Adrian F., Braunwald, Eugene, Redfield, Margaret M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Medical Association 2018
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6248105/
https://ncbi.nlm.nih.gov/pubmed/30398602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2018.14852
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