Association of Transforming Growth Factor β Polymorphism C−509T With Radiation-Induced Fibrosis Among Patients With Early-Stage Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial

IMPORTANCE: Whether genetic factors can identify patients at risk for radiation-induced fibrosis remains unconfirmed. OBJECTIVE: To assess the association between the C−509T variant allele in the promoter region of TGFB1 and breast fibrosis 3 years after radiotherapy. DESIGN, SETTING, AND PARTICIPAN...

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Vydáno v:JAMA Oncol
Hlavní autoři: Grossberg, Aaron J., Lei, Xiudong, Xu, Ting, Shaitelman, Simona F., Hoffman, Karen E., Bloom, Elizabeth S., Stauder, Michael C., Tereffe, Welela, Schlembach, Pamela J., Woodward, Wendy A., Buchholz, Thomas A., Smith, Benjamin D.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Medical Association 2018
Témata:
Original Investigation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6248087/
https://ncbi.nlm.nih.gov/pubmed/30027292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2018.2583
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