Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, next-generation sequencing, and microsatellite instability testing: a case series study

BACKGROUND: Colorectal sessile serrated adenoma/polyps (SSA/Ps) are considered early precursor lesions in the serrated neoplasia pathway. Recent studies have shown associations of SSA/Ps with lost MLH1 expression, a CpG island methylator phenotype, and BRAF mutations. However, the molecular biologic...

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Vydáno v:Diagn Pathol
Hlavní autoři: Murakami, Takashi, Akazawa, Yoichi, Yatagai, Noboru, Hiromoto, Takafumi, Sasahara, Noriko, Saito, Tsuyoshi, Sakamoto, Naoto, Nagahara, Akihito, Yao, Takashi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6247685/
https://ncbi.nlm.nih.gov/pubmed/30458818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13000-018-0771-3
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