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Ribosome Profiling Reveals HSP90 Inhibitor Effects on Stage-Specific Protein Synthesis in Leishmania donovani

The 90-kDa heat shock protein (HSP90) of eukaryotes is a highly abundant and essential chaperone required for the maturation of regulatory and signal proteins. In the protozoan parasite Leishmania donovani, causative agent of the fatal visceral leishmaniasis, HSP90 activity is essential for cell pro...

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Detalhes bibliográficos
Publicado no:mSystems
Main Authors: Bifeld, Eugenia, Lorenzen, Stephan, Bartsch, Katharina, Vasquez, Juan-José, Siegel, T. Nicolai, Clos, Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6247020/
https://ncbi.nlm.nih.gov/pubmed/30505948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSystems.00214-18
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