Improved Tolerability of a Salmonella enterica Serovar Typhimurium Live-Attenuated Vaccine Strain Achieved by Balancing Inflammatory Potential with Immunogenicity

A notable proportion of Salmonella-associated gastroenteritis in the United States is attributed to Salmonella enterica serovar Typhimurium. We have previously shown that live-attenuated S. Typhimurium vaccine candidate CVD 1921 (I77 ΔguaBA ΔclpP) was safe and immunogenic in rhesus macaques but was...

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Bibliografiset tiedot
Julkaisussa:Infect Immun
Päätekijät: Higginson, Ellen E., Ramachandran, Girish, Panda, Aruna, Shipley, Steven T., Kriel, Edwin H., DeTolla, Louis J., Lipsky, Michael, Perkins, Darren J., Salerno-Goncalves, Rosangela, Sztein, Marcelo B., Pasetti, Marcela F., Levine, Myron M., Tennant, Sharon M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2018
Aiheet:
Microbial Immunity and Vaccines
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6246900/
https://ncbi.nlm.nih.gov/pubmed/30249748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00440-18
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