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Histophilus somni Survives in Bovine Macrophages by Interfering with Phagosome-Lysosome Fusion but Requires IbpA for Optimal Serum Resistance

Histophilus somni is capable of intracellular survival within professional phagocytic cells, but the mechanism of survival is not understood. The Fic motif within the direct repeat (DR1)/DR2 domains of the IbpA fibrillary network protein of H. somni is cytotoxic to epithelial and phagocytic cells, w...

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Bibliografiske detaljer
Udgivet i:Infect Immun
Main Authors: Pan, Yu, Tagawa, Yuichi, Champion, Anna, Sandal, Indra, Inzana, Thomas J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2018
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6246896/
https://ncbi.nlm.nih.gov/pubmed/30201700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00365-18
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