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Improved Potency and Reduced Toxicity of the Antifungal Peptoid AEC5 Through Submonomer Modification
As proteolytically stable peptidomimetics, peptoids could serve as antifungal agents to supplement a therapeutic field wrought with toxicity issues. We report the improvement of an antifungal peptoid, AEC5, through an iterative structure-activity relationship study. A sarcosine scan was used to firs...
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| Publicado en: | Bioorg Med Chem Lett |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6246776/ https://ncbi.nlm.nih.gov/pubmed/30297282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.10.001 |
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