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Improved Potency and Reduced Toxicity of the Antifungal Peptoid AEC5 Through Submonomer Modification
As proteolytically stable peptidomimetics, peptoids could serve as antifungal agents to supplement a therapeutic field wrought with toxicity issues. We report the improvement of an antifungal peptoid, AEC5, through an iterative structure-activity relationship study. A sarcosine scan was used to firs...
Gorde:
| Argitaratua izan da: | Bioorg Med Chem Lett |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6246776/ https://ncbi.nlm.nih.gov/pubmed/30297282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.10.001 |
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