FOXO1 Deletion Reverses the Effect of Diabetic-Induced Impaired Fracture Healing

Type 1 diabetes impairs fracture healing. We tested the hypothesis that diabetes affects chondrocytes to impair fracture healing through a mechanism that involves the transcription factor FOXO1. Type 1 diabetes was induced by streptozotocin in mice with FOXO1 deletion in chondrocytes (Col2α1Cre(+).F...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Alharbi, Mohammed A., Zhang, Citong, Lu, Chanyi, Milovanova, Tatyana N., Yi, Leah, Ryu, Je Dong, Jiao, Hongli, Dong, Guangyu, O’Connor, J. Patrick, Graves, Dana T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245226/
https://ncbi.nlm.nih.gov/pubmed/30279162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0340
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