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Using single nucleotide variations in single-cell RNA-seq to identify subpopulations and genotype-phenotype linkage
Despite its popularity, characterization of subpopulations with transcript abundance is subject to a significant amount of noise. We propose to use effective and expressed nucleotide variations (eeSNVs) from scRNA-seq as alternative features for tumor subpopulation identification. We develop a linea...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6244222/ https://ncbi.nlm.nih.gov/pubmed/30459309 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-07170-5 |
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