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Significant drug–drug interaction between warfarin and nafcillin
Nafcillin, a beta-lactam semisynthetic penicillin, is highly resistant to penicillinase and is similar to other penicillins except that it is primarily metabolized in the liver. It is believed that nafcillin causes CYP3A4 enzyme induction which decreases warfarin’s half-life. The onset of CYP3A4 ind...
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| Udgivet i: | Ther Adv Drug Saf |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
SAGE Publications
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6243422/ https://ncbi.nlm.nih.gov/pubmed/30479741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2042098618796186 |
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