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Significant drug–drug interaction between warfarin and nafcillin

Nafcillin, a beta-lactam semisynthetic penicillin, is highly resistant to penicillinase and is similar to other penicillins except that it is primarily metabolized in the liver. It is believed that nafcillin causes CYP3A4 enzyme induction which decreases warfarin’s half-life. The onset of CYP3A4 ind...

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Bibliografische gegevens
Gepubliceerd in:Ther Adv Drug Saf
Hoofdauteurs: King, Cynthia A., Babcock, Kathleen M., Godios, Rhianna J., King, Benjamin S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: SAGE Publications 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6243422/
https://ncbi.nlm.nih.gov/pubmed/30479741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2042098618796186
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