A Catalytic and Selective Scissoring Molecular Tool for Quadruplex Nucleic Acids

[Image: see text] A copper complex embedded in the structure of a water-soluble naphthalene diimide has been designed to bind and cleave G-quadruplex DNA. We describe the properties of this ligand, including its catalytic activity in the generation of ROS. FRET melting, CD, NMR, gel sequencing, and...

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Vydáno v:J Am Chem Soc
Hlavní autoři: Nadai, Matteo, Doria, Filippo, Scalabrin, Matteo, Pirota, Valentina, Grande, Vincenzo, Bergamaschi, Greta, Amendola, Valeria, Winnerdy, Fernaldo Richtia, Phan, Anh Tuân, Richter, Sara N., Freccero, Mauro
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2018
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6242190/
https://ncbi.nlm.nih.gov/pubmed/30351011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b05337
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