Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16

Multipotent progenitors confirm their T cell-lineage identity in the DN2 pro-T cell stages, when expression of the essential transcription factor Bcl11b begins. In vivo and in vitro stage-specific deletions globally identified Bcl11b-controlled target genes in pro-T cells. Proteomic analysis reveale...

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Udgivet i:Nat Immunol
Main Authors: Hosokawa, Hiroyuki, Romero-Wolf, Maile, Yui, Mary A., Ungerbäck, Jonas, Quiloan, Maria L. G., Matsumoto, Masaki, Nakayama, Keiichi I., Tanaka, Tomoaki, Rothenberg, Ellen V.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6240390/
https://ncbi.nlm.nih.gov/pubmed/30374131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0238-4
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