Label-free imaging of amyloid plaques in Alzheimer’s disease with stimulated Raman scattering microscopy

One of the key pathological features of Alzheimer’s disease (AD) is the existence of extracellular deposition of amyloid plaques formed with misfolded amyloid-β (Aβ). The conformational change of proteins leads to enriched contents of β sheets, resulting in remarkable changes of vibrational spectra,...

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Udgivet i:Sci Adv
Main Authors: Ji, Minbiao, Arbel, Michal, Zhang, Lili, Freudiger, Christian W., Hou, Steven S., Lin, Dongdong, Yang, Xinju, Bacskai, Brian J., Xie, X. Sunney
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2018
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239428/
https://ncbi.nlm.nih.gov/pubmed/30456301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aat7715
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