Enzyme kinetics from circular dichroism of insulin reveals mechanistic insights into the regulation of insulin-degrading enzyme

Insulin-degrading enzyme (IDE) is a zinc metalloprotease that selectively degrades biologically important substrates associated with type 2 diabetes and Alzheimer’s disease (AD). As such, IDE is an attractive target for therapeutic innovations. A major requirement is an understanding of how other mo...

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Enregistré dans:
Détails bibliographiques
Publié dans:Biosci Rep
Auteurs principaux: Ivancic, Valerie A., Krasinski, Claire A., Zheng, Qiuchen, Meservier, Rebecca J., Spratt, Donald E., Lazo, Noel D.
Format: Artigo
Langue:Inglês
Publié: Portland Press Ltd. 2018
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239264/
https://ncbi.nlm.nih.gov/pubmed/30305381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20181416
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