Microbial signals drive pre–leukaemic myeloproliferation in a Tet2–deficient host

Somatic mutations in tet methylcytosine dioxygenase 2 (TET2), which encodes an epigenetic modifier enzyme, drive the development of haematopoietic malignancies(1–7). In both humans and mice, TET2 deficiency leads to increased self-renewal of haematopoietic stem cells with a net developmental bias to...

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Vydáno v:Nature
Hlavní autoři: Meisel, Marlies, Hinterleitner, Reinhard, Pacis, Alain, Chen, Li, Earley, Zachary M., Mayassi, Toufic, Pierre, Joseph F., Ernest, Jordan D., Galipeau, Heather J., Thuille, Nikolaus, Bouziat, Romain, Buscarlet, Manuel, Ringus, Daina L., Wang, Yitang, Li, Ye, Dinh, Vu, Kim, Sangman M., McDonald, Benjamin D., Zurenski, Matthew A., Musch, Mark W., Furtado, Glaucia C., Lira, Sergio A., Baier, Gottfried, Chang, Eugene B., Eren, A. Murat, Weber, Christopher R., Busque, Lambert, Godley, Lucy A., Verdú, Elena F., Barreiro, Luis B., Jabri, Bana
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238954/
https://ncbi.nlm.nih.gov/pubmed/29769727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-018-0125-z
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