Secretion of tumoricidal human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by recombinant Lactococcus lactis: optimization of in vitro synthesis conditions

BACKGROUND: Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively eliminates tumor cells. However, the short biological half-life of this molecule limits its potential use in the clinic. Our aim was to construct a recombinant strain of nonpathogenic Lactococcus lactis bacteria...

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Detalhes bibliográficos
Publicado no:Microb Cell Fact
Main Authors: Ciaćma, Katarzyna, Więckiewicz, Jerzy, Kędracka-Krok, Sylwia, Kurtyka, Magdalena, Stec, Małgorzata, Siedlar, Maciej, Baran, Jarek
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238363/
https://ncbi.nlm.nih.gov/pubmed/30446013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-018-1028-2
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