Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex

CRISPR/Cas gene studies were conducted in HeLa cells where either PGRMC1, TMEM97 or both proteins were removed via gene editing. A series of radioligand binding studies, confocal microscopy studies, and internalization of radiolabeled or fluorescently tagged LDL particles were then conducted in thes...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Riad, Aladdin, Zeng, Chenbo, Weng, Chi-Chang, Winters, Harrison, Xu, Kuiying, Makvandi, Mehran, Metz, Tyler, Carlin, Sean, Mach, Robert H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238005/
https://ncbi.nlm.nih.gov/pubmed/30443021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35430-3
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