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Structural Basis for Binding of Allosteric Drug Leads in the Adenosine A(1) Receptor
Despite intense interest in designing positive allosteric modulators (PAMs) as selective drugs of the adenosine A(1) receptor (A(1)AR), structural binding modes of the receptor PAMs remain unknown. Using the first X-ray structure of the A(1)AR, we have performed all-atom simulations using a robust G...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6237911/ https://ncbi.nlm.nih.gov/pubmed/30442899 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35266-x |
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