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SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions

We report a new class of artifacts in DNA methylation measurements from Illumina HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed hybridization to target DNA, often due to germline or somatic deletions and manifest as incorrectly reported intermediate methylation. The a...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Zhou, Wanding, Triche, Timothy J, Laird, Peter W, Shen, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237738/
https://ncbi.nlm.nih.gov/pubmed/30085201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky691
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