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Excessive glutamate stimulation impairs ACE2 activity through ADAM17-mediated shedding in cultured cortical neurons

The excitotoxicity of glutamate plays an important role in the progression of various neurological disorders via participating in inflammation and neuronal damage. In this study, we identified the role of excessive glutamate stimulation in the modulation of angiotensin-converting enzyme type 2 (ACE2...

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Bibliografiska uppgifter
I publikationen:Cell Mol Neurobiol
Huvudupphovsmän: Jiaxi, Xu, Sriramula, Srinivas, Lazartigues, Eric
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237671/
https://ncbi.nlm.nih.gov/pubmed/29766392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10571-018-0591-8
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