IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke

Stroke triggers a complex inflammatory process in which the balance between pro- and antiinflammatory mediators is critical for the development of the brain infarct. However, systemic changes may also occur in parallel with brain inflammation. Here we demonstrate that administration of recombinant I...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Zhang, Shenpeng R., Piepke, Marius, Chu, Hannah X., Broughton, Brad R.S., Shim, Raymond, Wong, Connie H.Y., Lee, Seyoung, Evans, Megan A., Vinh, Antony, Sakkal, Samy, Arumugam, Thiruma V., Magnus, Tim, Huber, Samuel, Gelderblom, Mathias, Drummond, Grant R., Sobey, Christopher G., Kim, Hyun Ah
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237219/
https://ncbi.nlm.nih.gov/pubmed/30232272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121560
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