Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma

To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22 423 control patients. We identify 5 new HL risk loci at 6p21.31 (rs649775; P = 2.11 × 10(−10)), 6q23.3 (rs1002658; P = 2....

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Vydáno v:Blood
Hlavní autoři: Sud, Amit, Thomsen, Hauke, Orlando, Giulia, Försti, Asta, Law, Philip J., Broderick, Peter, Cooke, Rosie, Hariri, Fadi, Pastinen, Tomi, Easton, Douglas F., Pharoah, Paul D. P., Dunning, Alison M., Peto, Julian, Canzian, Federico, Eeles, Rosalind, Kote-Jarai, ZSofia, Muir, Kenneth, Pashayan, Nora, Campa, Daniele, Hoffmann, Per, Nöthen, Markus M., Jöckel, Karl-Heinz, von Strandmann, Elke Pogge, Swerdlow, Anthony J., Engert, Andreas, Orr, Nick, Hemminki, Kari, Houlston, Richard S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2018
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6236462/
https://ncbi.nlm.nih.gov/pubmed/30194254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-06-855296
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