In vivo evidence for reduced ion channel expression in motor axons of patients with amyotrophic lateral sclerosis

KEY POINTS: The progressive loss of motor units in amyotrophic lateral sclerosis (ALS) is initially compensated for by the reinnervation of denervated muscle fibres by surviving motor axons. A disruption in protein homeostasis is thought to play a critical role in the pathogenesis of ALS. The change...

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Bibliographic Details
Published in:J Physiol
Main Authors: Howells, James, Matamala, José Manuel, Park, Susanna B., Garg, Nidhi, Vucic, Steve, Bostock, Hugh, Burke, David, Kiernan, Matthew C.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235931/
https://ncbi.nlm.nih.gov/pubmed/30175403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP276624
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