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Dual κ-agonist / μ-antagonist opioid receptor modulation reduces L-dopa induced dyskinesia and corrects dysregulated striatal changes in the non-human primate model of Parkinson’s disease
OBJECTIVE: Effective medical management of L-dopa induced dyskinesia (LID) remains an unmet need for patients with Parkinson’s disease (PD). Changes in opioid transmission in the basal ganglia associated with LID suggest a therapeutic opportunity. Here we determined the impact of modulating both mu...
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| Publicado no: | Ann Neurol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6235675/ https://ncbi.nlm.nih.gov/pubmed/25820831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24375 |
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