Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

The epigenetic transcription regulation mediated by 5-methylcytosine (5mC) has played a critical role in eukaryotic development. Demethylation of these epigenetic marks is accomplished by sequential oxidation by ten-eleven translocation dioxygenases (TET1-3), followed by the thymine-DNA glycosylase-...

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Veröffentlicht in:J Vis Exp
Hauptverfasser: Bhattacharya, Chayan, Dey, Aninda Sundar, Ayon, Navid J., Gutheil, William G., Mukherji, Mridul
Format: Artigo
Sprache:Inglês
Veröffentlicht: MyJove Corporation 2018
Schlagworte:
This Month in JoVE
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235521/
https://ncbi.nlm.nih.gov/pubmed/30371677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/57798
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