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The pharmacokinetics of dexmedetomidine in patients with obstructive jaundice: A clinical trial

OBJECTIVES: Dexmedetomidine, a highly selective central α(2)-agonist, undergoes mainly biotransformation in the liver. The pharmacokinetics of dexmedetomidine were significantly affected by hepatic insufficiency. The clearance of dexmedetomidine in patients with severe hepatic failure decreased by 5...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Song, Jin-Chao, Gao, Hao, Qiu, Hai-Bo, Chen, Qian-Bo, Cai, Mei-Hua, Zhang, Ma-Zhong, Lu, Zhi-Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235379/
https://ncbi.nlm.nih.gov/pubmed/30427948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0207427
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