Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: a new potential target for antifibrotic therapy

BACKGROUND: Fibrosis may be considered the hallmark of systemic sclerosis (SSc), the end stage triggered by different pathological events. Transforming growth factor-β (TGF-β) and platelet-derived growth factor BB (PDGF-BB) are profibrotic molecules modulating myofibroblast differentiation and proli...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Arthritis Res Ther
Päätekijät: Di Benedetto, Paola, Liakouli, Vasiliki, Ruscitti, Piero, Berardicurti, Onorina, Carubbi, Francesco, Panzera, Noemi, Di Bartolomeo, Salvatore, Guggino, Giuliana, Ciccia, Francesco, Triolo, Giovanni, Cipriani, Paola, Giacomelli, Roberto
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2018
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6235209/
https://ncbi.nlm.nih.gov/pubmed/30285896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1719-4
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