Efficient and Non-genotoxic RNA-Based Engineering of Human T Cells Using Tumor-Specific T Cell Receptors With Minimal TCR Mispairing

Genetic engineering of T cells with tumor specific T-cell receptors (TCR) is a promising strategy to redirect their specificity against cancer cells in adoptive T cell therapy protocols. Most studies are exploiting integrating retro- or lentiviral vectors to permanently introduce the therapeutic TCR...

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Bibliographische Detailangaben
Veröffentlicht in:Front Immunol
Hauptverfasser: Campillo-Davo, Diana, Fujiki, Fumihiro, Van den Bergh, Johan M. J., De Reu, Hans, Smits, Evelien L. J. M., Goossens, Herman, Sugiyama, Haruo, Lion, Eva, Berneman, Zwi N., Van Tendeloo, Viggo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234959/
https://ncbi.nlm.nih.gov/pubmed/30464762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02503
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