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Spatially-Restricting Bioorthogonal Nucleoside Biosynthesis Enables Selective Metabolic Labeling of the Mitochondrial Transcriptome
The cellular RNA pool in animals arises from two separate genomes stored in the nucleus and multiple mitochondria. Chemical methods to track nascent RNA synthesis are unable to distinguish between these two with stringency. Herein we report that spatially restricting bioorthogonal nucleoside biosynt...
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| Veröffentlicht in: | ACS Chem Biol |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6234202/ https://ncbi.nlm.nih.gov/pubmed/29756767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00262 |
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