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Spatially-Restricting Bioorthogonal Nucleoside Biosynthesis Enables Selective Metabolic Labeling of the Mitochondrial Transcriptome

The cellular RNA pool in animals arises from two separate genomes stored in the nucleus and multiple mitochondria. Chemical methods to track nascent RNA synthesis are unable to distinguish between these two with stringency. Herein we report that spatially restricting bioorthogonal nucleoside biosynt...

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Bibliografski detalji
Izdano u:ACS Chem Biol
Glavni autori: Nguyen, Kim, Aggarwal, Mahima B., Feng, Chao, Balderrama, Gabriela, Fazio, Michael, Mortazavi, Ali, Spitale, Robert C.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234202/
https://ncbi.nlm.nih.gov/pubmed/29756767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00262
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