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Inhibition of Pancreatic Cancer Panc1 Cell Migration by Omeprazole Is Dependent on Aryl Hydrocarbon Receptor Activation of JNK

Several aryl hydrocarbon receptor (AhR)-active pharmaceuticals were screened as inhibitors of pancreatic cancer cell invasion and identified two compounds, omeprazole, that inhibited invasion. Inhibition of highly invasive Panc1 cell invasion by omeprazole involves an AhR-dependent non-genomic pathw...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Res Commun
Main Authors: Jin, Un-Ho, Karki, Keshav, Kim, Sang-Bae, Safe, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6234016/
https://ncbi.nlm.nih.gov/pubmed/29758193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.05.061
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