Effect of Targeted Polymyxin B Hemoperfusion on 28-Day Mortality in Patients With Septic Shock and Elevated Endotoxin Level: The EUPHRATES Randomized Clinical Trial

IMPORTANCE: Polymyxin B hemoperfusion reduces blood endotoxin levels in sepsis. Endotoxin activity can be measured in blood with a rapid assay. Treating patients with septic shock and elevated endotoxin activity using polymyxin B hemoperfusion may improve clinical outcomes. OBJECTIVE: To test whethe...

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Bibliographische Detailangaben
Veröffentlicht in:JAMA
Hauptverfasser: Dellinger, R. Phillip, Bagshaw, Sean M., Antonelli, Massimo, Foster, Debra M., Klein, David J., Marshall, John C., Palevsky, Paul M., Weisberg, Lawrence S., Schorr, Christa A., Trzeciak, Stephen, Walker, Paul M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Medical Association 2018
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Original Investigation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233793/
https://ncbi.nlm.nih.gov/pubmed/30304428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2018.14618
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