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Conformational entropy of a single peptide controlled under force governs protease recognition and catalysis

An immense repertoire of protein chemical modifications catalyzed by enzymes is available as proteomics data. Quantifying the impact of the conformational dynamics of the modified peptide remains challenging to understand the decisive kinetics and amino acid sequence specificity of these enzymatic r...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Guerin, Marcelo E., Stirnemann, Guillaume, Giganti, David
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6233122/
https://ncbi.nlm.nih.gov/pubmed/30341218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803872115
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