Alpha1-Antitrypsin combines with plasma fatty acids and induces angiopoietin-like protein 4 expression

α1-Antitrypsin (A1AT) purified from human plasma upregulates expression and release of angiopoietin-like protein 4 (Angptl4) in adherent human blood monocytes and in human lung microvascular endothelial cells, providing a mechanism for the broad immune-regulatory properties of A1AT independent of it...

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Udgivet i:J Immunol
Main Authors: Frenzel, Eileen, Wrenger, Sabine, Brügger, Britta, Salipalli, Sandeep, Immenschuh, Stephan, Aggarwal, Nupur, Lichtinghagen, Ralf, Mahadeva, Ravi, Marcondes, A. Mario Q., Dinarello, Charles A., Welte, Tobias, Janciauskiene., Sabina
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232844/
https://ncbi.nlm.nih.gov/pubmed/26363050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500740
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