Identification of DKK-1 as a novel mediator of statin effects in human endothelial cells

This study shows that DKK-1, a member of the Dickkopf family and a regulator of the Wnt pathways, represents a novel target of statins which, through the inhibition of HMG-CoA reductase and of non-steroidal isoprenoid intermediates, exert extra-beneficial effect in preventing atherosclerosis beyond...

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Udgivet i:Sci Rep
Main Authors: Pontremoli, Marta, Brioschi, Maura, Baetta, Roberta, Ghilardi, Stefania, Banfi, Cristina
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232108/
https://ncbi.nlm.nih.gov/pubmed/30420710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35119-7
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