Regulating transcriptional activity by phosphorylation: A new mechanism for the ARX homeodomain transcription factor

Aristaless-related homeobox (ARX) gene encodes a paired-type homeodomain transcription factor with critical roles in development. Here we identify that ARX protein is phosphorylated. Using mass spectrometry and in vitro kinase assays we identify phosphorylation at serines 37, 67 and 174. Through yea...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mattiske, Tessa, Tan, May H., Dearsley, Oliver, Cloosterman, Desiree, Hii, Charles S., Gécz, Jozef, Shoubridge, Cheryl
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231642/
https://ncbi.nlm.nih.gov/pubmed/30419043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206914
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