Inhibition of AKT suppresses the initiation and progression of BRCA1-associated mammary tumors

Despite the high incidence of BRCA1-mutant breast cancer, few substantial improvements in preventing or treating such cancers have been made. Using a Brca1-mutant mouse model, we examined the contribution of AKT to the incidence and growth of Brca1-mutated mammary tumors. A haploinsufficiency of Akt...

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Publicat a:Int J Biol Sci
Autors principals: Baek, Hye Jung, Kim, Sun Eui, Kim, Jong Kwang, Shin, Dong Hoon, Kim, Tae Hyun, Kim, Kwang Gi, Deng, Chu-Xia, Kim, Sang Soo
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2018
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6231214/
https://ncbi.nlm.nih.gov/pubmed/30443181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.29242
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