A polymeric immunoglobulin—antigen fusion protein strategy for enhancing vaccine immunogenicity

In this study, a strategy based on polymeric immunoglobulin G scaffolds (PIGS) was used to produce a vaccine candidate for Mycobacterium tuberculosis. A genetic fusion construct comprising genes encoding the mycobacterial Ag85B antigen, an immunoglobulin γ‐chain fragment and the tailpiece from immun...

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Dettagli Bibliografici
Pubblicato in:Plant Biotechnol J
Autori principali: Webster, Gina R., van Dolleweerd, Craig, Guerra, Thais, Stelter, Szymon, Hofmann, Sven, Kim, Mi‐Young, Teh, Audrey Y‐H., Diogo, Gil Reynolds, Copland, Alastair, Paul, Mathew J., Hart, Peter, Reljic, Rajko, Ma, Julian K‐C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230950/
https://ncbi.nlm.nih.gov/pubmed/29682888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pbi.12932
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