Oleoylethanolamide modulates glucagon-like peptide-1 receptor agonist signaling and enhances exendin-4-mediated weight loss in obese mice

Long-acting glucagon-like peptide-1 (GLP-1) receptor (GLP-1R) agonists (GLP-1RA), such as exendin-4 (Ex4), promote weight loss. On the basis of a newly discovered interaction between GLP-1 and oleoylethanolamide (OEA), we tested whether OEA enhances GLP-1RA-mediated anorectic signaling and weight lo...

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Détails bibliographiques
Publié dans:Am J Physiol Regul Integr Comp Physiol
Auteurs principaux: Brown, Jacob D., McAnally, Danielle, Ayala, Jennifer E., Burmeister, Melissa A., Morfa, Camilo, Smith, Layton, Ayala, Julio E.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230892/
https://ncbi.nlm.nih.gov/pubmed/29949410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00459.2017
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